Tootoo made history when he was selected by Nashville in the fourth round, 98th overall, of the 2001 NHL draft.
He played most of his career with the Predators and also spent time with Detroit, New Jersey and Chicago. He last played in the 2016-17 season, when he had two goals and an assist in 50 games with the Blackhawks.
Tootoo had 65 goals, 96 assists and 1,010 penalty minutes over 723 NHL regular-season games and three goals, seven assists and 65 penalty minutes over 42 post-season games.
The 35-year-old from Rankin Inlet, Nunavut, announced his retirement in Brandon, Man., where he became a star with the Western Hockey League’s Wheat Kings.
"When I came to Brandon in 1999, I didn’t think of myself as an Indigenous role model, I was just a hockey player that would fight with everything I had to make the NHL," Tootoo said.
"This community embraced me and looked beyond my background and just judged me for how I played the game. And it’s pretty special and symbolic to come full circle and be back here to announce that I have retired from the NHL."